Max Lab
Jan 05, 2024
HLA-B27, also known as Human Leukocyte Antigen B27, is a protein found on the surface of white blood cells and is crucial for the immune system's identification of potential threats. The HLA-B27 test is a blood test that determines if one has a protein called HLA-B27 on the surface of the white blood cells. The HLA-B27 test examines blood samples to detect the presence of this antigen, aiding in the diagnosis of conditions like juvenile rheumatoid arthritis, autoimmune hepatitis, ankylosing spondylitis, rheumatoid arthritis type II, lupus erythematosus, or Crohn's disease.
The HLA-B27 test is performed like a routine blood test; healthcare professionals draw a small amount of blood, and no special preparation is necessary. The blood is analyzed in a medical laboratory to detect the presence or absence of this antigen on white blood cells. Potential outcomes include mild discomfort, soreness, swelling at the injection site, or lightheadedness. The duration of the test varies based on the technology employed, such as Flow Cytometry, or Polymerase Chain Reaction (PCR).
There are two types of HLA B27 test:
The doctor may prescribe the HLA-B27 test if one has the following symptoms: -
Here are some of the common illnesses associated with the HLA-B27 gene:
The HLA-B27 test is frequently recommended by doctors to help detect and diagnose certain autoimmune diseases, particularly ankylosing spondylitis. It may be advised if a doctor suspects this specific inflammatory arthritis based on symptoms like neck stiffness, back pain, chest tightness, etc. Individuals with a family history of ankylosing spondylitis may also benefit from HLA-B27 screening.
Results are reported as either positive or negative for the presence of HLA-B27 antigen.
Positive Result:
However, a positive result alone does not confirm the diagnosis of any disease. Other clinical criteria are also considered.
Negative Result:
However, some patients may still develop the conditions though HLA-B27 status is negative. It is not completely exclusionary.
HLA-B27 test results should always be interpreted along with clinical symptoms, medical history, and other diagnostic tests. If the test result is positive with relevant symptoms, it may assist healthcare professionals in diagnosing and managing certain autoimmune disorders. It is important to discuss the implications of HLA-B27 test results with a healthcare provider for better understanding.
If one is experiencing similar symptoms or has been advised by a doctor to undergo the HLA-B27 test, book a test at Max Lab. The HLA-B27 test price varies from lab to lab. When selecting a laboratory for any diagnostic test, consider factors like patient safety, care, and the professional conduct of the staff.
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